INDICATIONS

* Anaphylaxis, asthma, severe hypersensitivity reactions

* Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica

* Systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease (other than systemic sclerosis), polyarteritis nodosa, sarcoidosis

* Minimal change nephrotic syndrome, acute interstitial nephritis

* Rheumatic carditis

* Ulcerative colitis, Crohn's disease

* Uveitis, optic neuritis

* Autoimmune haemolytic anaemia, idiopathic thrombocyto¬penic purpura

* Acute and lymphatic leukaemia, malignant lymphoma, multiple myeloma

* Immune suppression in transplantation

DOSAGE AND ADMINISTRATION

Adults:

* For acute disorders: Up to 120 mg/day Deflaxen (Deflazacort) may need to be given initially. Maintenance doses in most conditions are within the range 3-18 mg/day.

* Rheumatoid arthritis: The maintenance dose is usually within the range 3-18 mg/day. The smallest effective dose should be used and increased if necessary.

* Bronchial asthma: In the treatment of an acute attack, high doses of 48-72 mg/day may be needed depending on severity and gradually reduced once the attack has been controlled. For maintenance in chronic asthma, doses should be titrated to the lowest dose that controls symptoms.

* Other conditions: The dose of Deflaxen (Deflazacort) depends on clinical need titrated to the lowest effective dose for maintenance. Starting doses may be estimated on the basis of the ratio of 5 mg prednisone or prednisolone to 6 mg Deflaxen (Deflazacort).

Children:

Alternate day administration may be appropriate. Doses of Deflaxen (Deflazacort) usually lie in the range of 0.25-1.5 mg/kg/day. The following ranges provide general guidance: * Juvenile chronic arthritis: The usual maintenance dose is between 0.25 and 1.0 mg/kg/day.

* Nephrotic syndrome: Initial dose is usually 1.5 mg/kg/day followed by down titration according to clinical need. * Bronchial asthma: The initial dose should be between 0.25-1.0 mg/kg on alternate days. 
 

FIND A PRODUCT